diff --git a/libsanitizer/configure b/libsanitizer/configure
index d3de3dbba51..d4ee0fac3e7 100755
--- a/libsanitizer/configure
+++ b/libsanitizer/configure
@@ -17045,9 +17045,16 @@ else
 $as_echo "no" >&6; }
 fi
 
-EXTRA_CFLAGS="$EXTRA_CFLAGS $CET_FLAGS"
-EXTRA_CXXFLAGS="$EXTRA_CXXFLAGS $CET_FLAGS"
-EXTRA_ASFLAGS=$CET_FLAGS
+# Always set -D_LARGEFILE_SOURCE -D_FILE_OFFSET_BITS=64 to sync with LLVM,
+# and keep struct *stat* have the same size.
+case "${host}" in
+  mips*-*) FILE64_FLAGS="-D_LARGEFILE_SOURCE -D_FILE_OFFSET_BITS=64" ;;
+  *) FILE64_FLAGS="" ;;
+esac
+
+EXTRA_CFLAGS="$EXTRA_CFLAGS $CET_FLAGS $FILE64_FLAGS"
+EXTRA_CXXFLAGS="$EXTRA_CXXFLAGS $CET_FLAGS $FILE64_FLAGS"
+EXTRA_ASFLAGS="$CET_FLAGS $FILE64_FLAGS"
 
 
 
diff --git a/libsanitizer/configure.ac b/libsanitizer/configure.ac
index ad49f29db7e..04cd8910ed6 100644
--- a/libsanitizer/configure.ac
+++ b/libsanitizer/configure.ac
@@ -416,8 +416,16 @@ GCC_BASE_VER
 
 # Add CET specific flags if Intel CET is enabled.
 GCC_CET_FLAGS(CET_FLAGS)
-EXTRA_CFLAGS="$EXTRA_CFLAGS $CET_FLAGS"
-EXTRA_CXXFLAGS="$EXTRA_CXXFLAGS $CET_FLAGS"
+
+# Always set -D_LARGEFILE_SOURCE -D_FILE_OFFSET_BITS=64 to sync with LLVM,
+# and keep struct *stat* have the same size.
+case "${host}" in
+  mips*-*) FILE64_FLAGS="-D_LARGEFILE_SOURCE -D_FILE_OFFSET_BITS=64" ;;
+  *) FILE64_FLAGS="" ;;
+esac
+
+EXTRA_CFLAGS="$EXTRA_CFLAGS $CET_FLAGS $FILE64_FLAGS"
+EXTRA_CXXFLAGS="$EXTRA_CXXFLAGS $CET_FLAGS $FILE64_FLAGS"
 EXTRA_ASFLAGS=$CET_FLAGS
 AC_SUBST(EXTRA_ASFLAGS)
 AC_SUBST(EXTRA_CFLAGS)